Nature Neuroscience, Published online: 11 November 2025; doi:10.1038/s41593-025-02108-9In this issue of Nature Neuroscience, Golden et al. unveil a mouse model that enables in vivo ‘switching’ from the Alzheimer’s risk gene APOE4 to the protective gene APOE2. This genetic conversion reshapes Alzheimer’s disease-related metabolism, reduces neuropathology, and enhances cognition, demonstrating the beneficial effects of APOE genetic targeting as a promising therapeutic strategy.
If you do not see content above, kindly GO TO SOURCE.
Not all publishers encode content in a way that enables republishing at Neuro.vip.
This post is Copyright: | November 11, 2025
NeuroScience