Nature Neuroscience, Published online: 03 October 2025; doi:10.1038/s41593-025-02062-6Ionescu, Ankol et al. show that, in ALS mouse and iPSC models, TDP-43 aggregation at NMJs stems from aberrant axonal translation, normally repressed by muscle EV-derived miR126. Loss of miR126 in ALS increases TDP-43 buildup, impairs local synthesis and triggers degeneration.
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This post is Copyright: | October 3, 2025
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