Nature Neuroscience, Published online: 08 August 2024; doi:10.1038/s41593-024-01729-wIn Caenorhabditis elegans, loss of the transcription factors FOS-1 and EGL-43 — orthologs of human FOS and MECOM, respectively — severely reduces presynaptic gene expression in dopaminergic neurons. These transcription factors form an activity-regulated positive feedback loop, which modulates the expression of synaptic genes and genetic programs to promote synapse formation.
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This post is Copyright: | August 8, 2024
Nature Neuroscience