Nature Neuroscience, Published online: 29 May 2026; doi:10.1038/s41593-026-02297-xA cellular explanation for how tau aggregates into fibrils in Alzheimer’s disease has been elusive. This paper identifies the failure of ‘neuroproteasomes’ as sufficient to convert tau into paired helical filaments, a process regulated by ApoE and aging.
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This post is Copyright: | May 29, 2026
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