Nature Neuroscience, Published online: 20 November 2025; doi:10.1038/s41593-025-02138-3Early tactile deficits in patients with Alzheimer disease (AD) and AD mouse models map to tau pathology in spinal cholecystokinin (CCK) neurons. In AD mice, reducing tau or c-Maf levels in spinal CCK neurons restores touch and benefits cognition, suggesting that these deficits are a noninvasive peripheral indication of early AD and offer a tractable target for intervention.
If you do not see content above, kindly GO TO SOURCE.
Not all publishers encode content in a way that enables republishing at Neuro.vip.
This post is Copyright: | November 20, 2025
NeuroScience