Nature Neuroscience, Published online: 29 February 2024; doi:10.1038/s41593-024-01593-8Astrocytes have important roles in disease and are difficult to modulate, owing to a paucity of known targets. Clayton et al. develop a screening platform to unbiasedly identify modulators of astrocyte reactivity. They discover that HDAC3 inhibitors regulate astrocyte transitions into their reactive phenotype in vitro and in vivo.

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This post is Copyright: Francesco Limone | February 29, 2024
Nature Neuroscience