Nature Neuroscience, Published online: 11 November 2024; doi:10.1038/s41593-024-01777-2Tyrosine kinase 2 (TYK2) critically regulates tau levels and aggregation by phosphorylating tau’s tyrosine 29. Partial inhibition of TYK2 mitigates tau pathologies in cells and mice, highlighting TYK2 as a potential therapeutic target for Alzheimer’s disease and other tauopathies.
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This post is Copyright: Jiyoen Kim | November 11, 2024
Nature Neuroscience