by Clinical Neuropsychologist Online | Wednesday, November 11, 2026 | Dementia
Abstract BACKGROUND CD8+ T-cell–mediated neuroimmune activation increases with aging and contributes to Alzheimer’s disease (AD), yet the molecular cues that drive their recruitment into the brain remain largely undefined. METHODS We quantified Cathepsin E...
by Clinical Neuropsychologist Online | Wednesday, November 11, 2026 | Dementia
Abstract INTRODUCTION Diabetes mellitus (DM) is a major risk factor for dementia, yet it remains unclear whether DM accelerates cognitive decline through amyloid beta (Aβ) or tau accumulation in Alzheimer’s disease (AD). METHODS In this study, we included 2784...
by Clinical Neuropsychologist Online | Wednesday, November 11, 2026 | Dementia
Abstract Alzheimer’s disease and related dementias (ADRD) pose a global public health challenge, and epidemiological evidence underscores profound disparities in ADRD risk and outcomes that are rooted in social/structural determinants of health (S/SDOH). Yet,...
by Clinical Neuropsychologist Online | Wednesday, November 11, 2026 | Dementia
Abstract Alzheimer’s disease (AD), which is characterized by the progressive accumulation of amyloid beta plaques and neurofibrillary tangles (NFTs), metabolic dysfunction, and neuroinflammation, is the most prevalent neurodegenerative disorder. The distinct...
by Clinical Neuropsychologist Online | Monday, November 9, 2026 | Dementia
Abstract INTRODUCTION Dementia prevention research increasingly uses multimodal interventions. Harmonized biomarker practices are essential to enable comparable cross-population analysis with initiatives such as the World-Wide FINGERS (WW-FINGERS) network contributing...
