by Clinical Neuropsychologist | Wednesday, July 24, 2024 | Dementia
Abstract INTRODUCTION Dementia is a multifactorial disease with Alzheimer’s disease (AD) and vascular dementia (VaD) pathologies making the largest contributions. Yet, most genome-wide association studies (GWAS) focus on AD. METHODS We conducted a GWAS of...
by Clinical Neuropsychologist | Tuesday, July 23, 2024 | Dementia
Abstract INTRODUCTION Tau-positron emission tomography (PET) outcome data of patients with Alzheimer’s disease (AD) cannot currently be meaningfully compared or combined when different tracers are used due to differences in tracer properties, instrumentation,...
by Clinical Neuropsychologist | Tuesday, July 23, 2024 | Dementia
Abstract INTRODUCTION Cerebrospinal fluid (CSF) tau phosphorylation at multiple sites is associated with cortical amyloid and other pathologic changes in Alzheimer’s disease. These relationships can be non-linear. We used an artificial neural network to assess...
by Clinical Neuropsychologist | Tuesday, July 23, 2024 | Dementia
Abstract INTRODUCTION Understanding attitudes toward participation among diverse preclinical Alzheimer’s disease (AD) trial participants could yield insights to instruct future recruitment. METHODS Using data from the Anti-Amyloid Treatment in Asymptomatic AD...
by Clinical Neuropsychologist | Tuesday, July 23, 2024 | Dementia
Abstract INTRODUCTION Understanding early neuropathological changes and their associations with cognition may aid dementia prevention. This study investigated associations of cerebral amyloid and tau positron emission tomography (PET) retention with cognition in a...