by Clinical Neuropsychologist Online | Monday, August 24, 2026 | Dementia
Abstract INTRODUCTION Obesity may increase Alzheimer’s disease (AD) risk, yet the underlying mechanisms remain unclear. METHODS We investigated this link through global epidemiology, Mendelian randomization (MR), transcriptomics, clinical cohort validation, and...
by Clinical Neuropsychologist Online | Saturday, August 22, 2026 | Dementia
Abstract INTRODUCTION Blood-based biomarkers are essential for early detection, monitoring, and therapeutic development in Alzheimer’s disease (AD) and related dementia (ADRD), but current assays lack brain cell specificity and sensitivity to low-abundant...
by Clinical Neuropsychologist Online | Saturday, August 22, 2026 | Dementia
Abstract INTRODUCTION SORL1 encodes the sorting receptor SORLA, a major genetic contributor to Alzheimer’s disease (AD). Although SORL1 loss disrupts endosomal trafficking and promotes amyloidogenic amyloid precursor protein (APP) processing, the functional...
by Clinical Neuropsychologist Online | Saturday, August 22, 2026 | Dementia
Concordant subjective-memory and objective-cognition decline showed the strongest and most reproducible association with incident functional dependence across four aging cohorts. Abstract INTRODUCTION The prognostic value of concurrent changes in subjective memory and...
by Clinical Neuropsychologist Online | Saturday, August 22, 2026 | Dementia
Abstract INTRODUCTION Neuroinflammatory processes may play a central role in promoting mixed pathologies and cognitive impairment in the oldest-old. We hypothesize that elevated neuroinflammation, indicated by reactive astrocytosis, acts on cerebrovascular disease and...
