by Clinical Neuropsychologist Online | Wednesday, September 30, 2026 | Dementia
Abstract INTRODUCTION Plasma high-density lipoprotein (HDL) varies in size. We examined the associations between HDL subclasses and their lipid composition and incident dementia risk in older adults. METHODS We included 23,790 United Kingdom (UK) Biobank (UKB) and 147...
by Clinical Neuropsychologist Online | Wednesday, September 30, 2026 | Dementia
Abstract INTRODUCTION Metabolic stress increases Alzheimer’s disease (AD) risk, but mechanisms linking metabolic dysfunction to neuroimmune dysregulation remain unclear. METHODS We assessed cognition in community-dwelling participants and used high-fat diet...
by Clinical Neuropsychologist Online | Wednesday, September 30, 2026 | Dementia
Abstract INTRODUCTION Excitation–inhibition (E/I) imbalance has been proposed as an early circuit-level mechanism in Alzheimer’s disease (AD), but its relationship to molecular pathology and cognition in humans remains unclear. METHODS We integrated biophysical...
by Clinical Neuropsychologist Online | Wednesday, September 30, 2026 | Dementia
Abstract INTRODUCTION Environmental exposures contribute substantially to Alzheimer’s disease and related dementias (ADRD), yet comprehensive exposome-wide investigations systematically evaluating multi-domain environmental factors remain limited and lacking...
by Clinical Neuropsychologist Online | Tuesday, September 29, 2026 | Dementia
Dementia, Ahead of Print. In the context of global demographic change, the number of patients with Alzheimer’s disease (AD) and other forms of dementia is steadily increasing. These individuals require ongoing care but often struggle to communicate their needs and...
