by Clinical Neuropsychologist Online | Monday, August 31, 2026 | Dementia
Abstract Artificial intelligence (AI) is rapidly entering dementia clinical practice, offering opportunities across the care continuum. However, cognitive decline creates a unique ethical challenge. This perspective article proposes a strategy to ensure the...
by Clinical Neuropsychologist Online | Monday, August 31, 2026 | Dementia
Abstract INTRODUCTION Apolipoprotein E (APOE) ε4 is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD), but its contribution to disease pathogenesis remains incompletely understood. METHODS Here, we integrate proteomic profiling of plasma...
by Clinical Neuropsychologist Online | Monday, August 31, 2026 | Dementia
Abstract INTRODUCTION The social exposome is increasingly recognized as a key determinant for cognitive health. Adverse policing represents an understudied aspect of the social exposome, reflecting persistent encounters with punitive surveillance and law enforcement...
by Clinical Neuropsychologist Online | Monday, August 31, 2026 | Dementia
Abstract INTRODUCTION Intrinsic functional connectivity network abnormalities in C9orf72 hexanucleotide repeat expansion carriers emerge during the asymptomatic phase, yet longitudinal studies remain limited. We examined cross-sectional abnormalities and longitudinal...
by Clinical Neuropsychologist Online | Sunday, August 30, 2026 | Dementia
Abstract INTRODUCTION Longitudinal diagnostic and prognostic validity of plasma phosphorylated tau217 (p-tau217) in Alzheimer’s disease (AD) remains uncertain. METHODS In this multi-cohort study of 2117 individuals, we established baseline plasma p-tau217...
