by Clinical Neuropsychologist | Wednesday, July 17, 2024 | Dementia
Abstract INTRODUCTION Aging is one of the risk factors for the early onset of Alzheimer’s disease (AD). We previously discovered that the age-dependent increase in Ubiquitin Conjugating Enzyme E2 N (UBE2N) plays a role in the accumulation of misfolded proteins...
by Clinical Neuropsychologist | Tuesday, July 16, 2024 | Dementia
Abstract Extracellular vesicles (EVs) hold promise as a source of disease biomarkers. The diverse molecular cargo of EVs can potentially indicate the status of their tissue of origin, even against the complex background of whole plasma. The main tools currently...
by Clinical Neuropsychologist | Saturday, July 13, 2024 | Dementia
Abstract INTRODUCTION Despite parallel research indicating amyloid-β accumulation, alterations in cortical neurophysiological signaling, and multi-system neurotransmitter disruptions in Alzheimer’s disease (AD), the relationships between these phenomena remains...
by Clinical Neuropsychologist | Saturday, July 13, 2024 | Dementia
Abstract INTRODUCTION This study aimed to explore the potential of whole brain white matter patterns as novel neuroimaging biomarkers for assessing cognitive impairment and disability in older adults. METHODS We conducted an in-depth analysis of magnetic resonance...
by Clinical Neuropsychologist | Saturday, July 13, 2024 | Dementia
Abstract INTRODUCTION Limited observational windows lead to conflicting results in studies examining educational differences in Alzheimer’s disease and related dementias (ADRD) risk, due to observational window bias relative to onset of accelerated cognitive...
