by Clinical Neuropsychologist | Monday, July 8, 2024 | Dementia
Abstract INTRODUCTION More robust non-human primate models of Alzheimer’s disease (AD) will provide new opportunities to better understand the pathogenesis and progression of AD. METHODS We designed a CRISPR/Cas9 system to achieve precise genomic deletion of...
by Clinical Neuropsychologist | Sunday, July 7, 2024 | Dementia
Abstract We assessed which coping strategies (problem-focused, emotion-focused, dysfunctional) mediate the association between caregivers’ understanding of dementia as terminal and their distress. A total of 215 caregivers of community-dwelling persons with severe...
by Clinical Neuropsychologist | Saturday, July 6, 2024 | Dementia
Abstract INTRODUCTION We aimed to unravel the underlying pathophysiology of the neurodegeneration (N) markers neurogranin (Ng), neurofilament light (NfL), and hippocampal volume (HCV), in Alzheimer’s disease (AD) using cerebrospinal fluid (CSF) proteomics....
by Clinical Neuropsychologist | Saturday, July 6, 2024 | Dementia
Abstract INTRODUCTION Understanding longitudinal change in key plasma biomarkers will aid in detecting presymptomatic Alzheimer’s disease (AD). METHODS Serial plasma samples from 424 Wisconsin Registry for Alzheimer’s Prevention participants were analyzed...
by Clinical Neuropsychologist | Saturday, July 6, 2024 | Dementia
Abstract INTRODUCTION There is limited evidence regarding the rate of long-term cognitive decline after traumatic brain injury (TBI) among older adults. METHODS In this prospective cohort study, time-varying TBI was defined by self-report and International...
