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Proteins linking APOE ɛ4 with Alzheimer’s disease

by Clinical Neuropsychologist | Monday, June 10, 2024 | Dementia

Abstract INTRODUCTION The ɛ4 allele of the apolipoprotein E gene (APOE ɛ4) is the strongest genetic risk factor for Alzheimer’s disease (AD), but the mechanisms connecting APOE ɛ4 to AD are not clear. METHODS Participants (n = 596) were from two...

Effect of vigorous‐intensity physical activity on incident cognitive impairment in high‐risk hypertension

by Clinical Neuropsychologist | Thursday, June 6, 2024 | Dementia

Abstract INTRODUCTION We investigated the effect vigorous physical activity (VPA) on the risk of incident mild cognitive impairment (MCI) and probable dementia among individuals with high-risk hypertension. METHODS Baseline self-reported frequency of VPA was...

fNIRS as a biomarker for individuals with subjective memory complaints and MCI

by Clinical Neuropsychologist | Wednesday, June 5, 2024 | Dementia

Abstract INTRODUCTION Identifying individuals at risk of developing dementia is crucial for early intervention. Mild cognitive impairment (MCI) and subjective memory complaints (SMCs) are considered its preceding stages. This study aimed to assess the utility of...

Social determinants of health but not global genetic ancestry predict dementia prevalence in Latin America

by Clinical Neuropsychologist | Wednesday, June 5, 2024 | Dementia

Abstract INTRODUCTION Leveraging the nonmonolithic structure of Latin America, which represents a large variability in social determinants of health (SDoH) and high levels of genetic admixture, we aim to evaluate the relative contributions of SDoH and genetic ancestry...

Mapping the interplay of atrial fibrillation, brain structure, and cognitive dysfunction

by Clinical Neuropsychologist | Wednesday, June 5, 2024 | Dementia

Abstract INTRODUCTION Atrial fibrillation (AF) is associated with an elevated risk of cognitive impairment and dementia. Understanding the cognitive sequelae and brain structural changes associated with AF is vital for addressing ensuing health care needs. METHODS AND...
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