by Clinical Neuropsychologist | Thursday, June 27, 2024 | Dementia
Abstract INTRODUCTION Motor function has correlated with longevity and functionality; however, there is limited research on those with Alzheimer’s disease (AD). We studied the association between motor functionality and AD pathology in primary motor and medial...
by Clinical Neuropsychologist | Thursday, June 27, 2024 | Dementia
Abstract INTRODUCTION Cognitive impairment is a core feature of Down syndrome (DS), and the underlying neurobiological mechanisms remain unclear. Translation dysregulation is linked to multiple neurological disorders characterized by cognitive impairments....
by Clinical Neuropsychologist | Wednesday, June 26, 2024 | Dementia
Abstract INTRODUCTION Sequence variants in TMEM106B have been associated with an increased risk of developing dementia. METHODS As part of our efforts to generate a set of mouse lines in which we replaced the mouse Tmem106b gene with a human TMEM106B gene comprised of...
by Clinical Neuropsychologist | Wednesday, June 26, 2024 | Dementia
Abstract INTRODUCTION A noncoding variant (rs35349669) within INPP5D , a lipid and protein phosphatase restricted to microglia in the brain, is linked to increased susceptibility to Alzheimer’s disease (AD). While Inpp5d is well-studied in amyloid pathology, its...
by Clinical Neuropsychologist | Wednesday, June 26, 2024 | Dementia
Abstract INTRODUCTION Inpp5d is genetically associated with Alzheimer’s disease risk. Loss of Inpp5d alters amyloid pathology in models of amyloidosis. Inpp5d is expressed predominantly in microglia but its function in brain is poorly understood. METHODS We...
