by Clinical Neuropsychologist | Friday, June 21, 2024 | Dementia
Dementia, Volume 23, Issue 7, Page 1103-1125, October 2024. IntroductionPeople living with young-onset dementia and their care-partners are at risk of a range of adverse mental health outcomes and social isolation. There are few interventions aimed at supporting...
by Clinical Neuropsychologist | Friday, June 21, 2024 | Dementia
Abstract INTRODUCTION The understanding of the pathological events in Alzheimer’s disease (AD) has advanced dramatically, but the successful translation from rodent models into efficient human therapies is still problematic. METHODS To examine how tau pathology...
by Clinical Neuropsychologist | Thursday, June 20, 2024 | Dementia
Abstract INTRODUCTION Premenopausal bilateral oophorectomy (PBO) is associated with later-life cognition, but the underlying brain changes remain unclear. We assessed the impact of PBO and PBO age on white matter integrity. METHODS Female participants with regional...
by Clinical Neuropsychologist | Thursday, June 20, 2024 | Dementia
Abstract INTRODUCTION Amyloid beta (Aβ) impairs the cerebral blood flow (CBF) increase induced by neural activity (functional hyperemia). Tissue plasminogen activator (tPA) is required for functional hyperemia, and in mouse models of Aβ accumulation tPA deficiency...
by Clinical Neuropsychologist | Thursday, June 20, 2024 | Dementia
Dementia, Volume 23, Issue 8, Page 1327-1353, November 2024. The abuse of older adults is a societal, and legal issue. A person living with dementia is at high risk for abuse due to their physical and cognitive decline.ObjectivesThis review examined the evidence for...
