by Clinical Neuropsychologist | Monday, June 3, 2024 | Dementia
Abstract INTRODUCTION Altered immune signatures are emerging as a central theme in neurodegenerative disease, yet little is known about immune responses in early-onset Alzheimer’s disease (EOAD). METHODS We examined single-cell RNA-sequencing (scRNA-seq) data...
by Clinical Neuropsychologist | Monday, June 3, 2024 | Dementia
Abstract INTRODUCTION Individuals referred to as Non-Demented with Alzheimer’s Neuropathology (NDAN) exhibit cognitive resilience despite presenting Alzheimer’s disease (AD) histopathological signs. Investigating the mechanisms behind this resilience may...
by Clinical Neuropsychologist | Monday, June 3, 2024 | Dementia
Abstract INTRODUCTION Recent growth in the functionality and use of technology has prompted an increased interest in the potential for remote or decentralized clinical trials in dementia. There are many potential benefits associated with decentralized medication...
by Clinical Neuropsychologist | Monday, June 3, 2024 | Dementia
Abstract Alzheimer’s disease (AD) is a neurodegenerative disease that involves multiple systems in the body. Numerous recent studies have revealed bidirectional crosstalk between the brain and bone, but the interaction between bone and brain in AD remains...
by Clinical Neuropsychologist | Sunday, June 2, 2024 | Dementia
Abstract INTRODUCTION Familial Alzheimer’s disease (fAD) is heterogeneous in terms of age at onset and clinical presentation. A greater understanding of the pathogenicity of fAD variants and how these contribute to heterogeneity will enhance our understanding of...
