by Clinical Neuropsychologist Online | Friday, June 28, 2024 | Dementia
Abstract INTRODUCTION To investigate the role of a novel type of protein kinase C delta (PKCδ) in the neuroinflammation of Alzheimer’s disease (AD). METHODS We analyzed PKCδ and inflammatory cytokines levels in cerebrospinal fluid (CSF) of AD and normal...
by Clinical Neuropsychologist Online | Thursday, June 27, 2024 | Dementia
Abstract INTRODUCTION Motor function has correlated with longevity and functionality; however, there is limited research on those with Alzheimer’s disease (AD). We studied the association between motor functionality and AD pathology in primary motor and medial...
by Clinical Neuropsychologist Online | Thursday, June 27, 2024 | Dementia
Abstract INTRODUCTION Cognitive impairment is a core feature of Down syndrome (DS), and the underlying neurobiological mechanisms remain unclear. Translation dysregulation is linked to multiple neurological disorders characterized by cognitive impairments....
by Clinical Neuropsychologist Online | Wednesday, June 26, 2024 | Dementia
Abstract INTRODUCTION Sequence variants in TMEM106B have been associated with an increased risk of developing dementia. METHODS As part of our efforts to generate a set of mouse lines in which we replaced the mouse Tmem106b gene with a human TMEM106B gene comprised of...
by Clinical Neuropsychologist Online | Wednesday, June 26, 2024 | Dementia
Abstract INTRODUCTION A noncoding variant (rs35349669) within INPP5D , a lipid and protein phosphatase restricted to microglia in the brain, is linked to increased susceptibility to Alzheimer’s disease (AD). While Inpp5d is well-studied in amyloid pathology, its...
