by Clinical Neuropsychologist Online | Monday, June 17, 2024 | Dementia
Abstract INTRODUCTION Tau aggregation into neurofibrillary tangles in Alzheimer’s disease (AD) is a dynamic process involving changes in tau phosphorylation, isoform composition, and morphology. To facilitate studies of tangle maturity, we developed an image...
by Clinical Neuropsychologist Online | Monday, June 17, 2024 | Dementia
Abstract INTRODUCTION Intraneuronal inclusions composed of tau protein are found in Alzheimer’s disease (AD) and other tauopathies. Tau normally binds microtubules (MTs), and its disengagement from MTs and misfolding in AD is thought to result in MT...
by Clinical Neuropsychologist Online | Monday, June 17, 2024 | Dementia
Abstract Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of amyloid protein in the walls of cerebral blood vessels. This deposition of amyloid causes damage to the cerebral vasculature, resulting in blood-brain barrier disruption, cerebral...
by Clinical Neuropsychologist Online | Saturday, June 15, 2024 | Dementia
Abstract INTRODUCTION TAR DNA-binding protein 43 (TDP-43) is a highly prevalent proteinopathy that is involved in neurodegenerative processes, including axonal damage. To date, no ante mortem biomarkers exist for TDP-43, and few studies have directly assessed its...
by Clinical Neuropsychologist Online | Saturday, June 15, 2024 | Dementia
Abstract INTRODUCTION The contribution of neuropsychological assessments to risk assessment for incident dementia is underappreciated. METHODS We analyzed neuropsychological testing results in dementia-free participants in the Atherosclerosis Risk in Communities...
