by Clinical Neuropsychologist | Thursday, March 20, 2025 | Dementia
Abstract INTRODUCTION Autosomal dominant Alzheimer’s disease (ADAD) through genetic mutations can result in near complete expression of the disease. Tracking AD pathology development in an ADAD cohort of Presenilin-1 (PSEN1) E280A carriers’ mutation has allowed...
by Clinical Neuropsychologist | Thursday, March 20, 2025 | Dementia
Abstract INTRODUCTION Accelerated long-term forgetting (LTF) might be an early marker of subtle memory changes in older adults at risk for Alzheimer’s disease (AD). We leveraged remote, multi-day digital testing to characterize LTF in older adults and...
by Clinical Neuropsychologist | Thursday, March 20, 2025 | Dementia
Abstract INTRODUCTION Alzheimer’s disease (AD) is characterized by amyloid pathology and neuroinflammation, leading to cognitive decline. Targeting histone deacetylase-11 (HDAC11) offers a novel therapeutic strategy due to its role in immune regulation. METHODS...
by Clinical Neuropsychologist | Thursday, March 20, 2025 | Dementia
Abstract Interventions addressing modifiable personal and environmental factors are critical to optimize dementia mealtime care, caregiving, and outcomes. This review synthesized the characteristics and effects of non-pharmacological interventions on mealtime care and...
by Clinical Neuropsychologist | Thursday, March 20, 2025 | Dementia
Abstract INTRODUCTION Plasma biomarkers sensitive to Alzheimer’s disease (AD) proteinopathy prior to the onset of dementia have significant implications for early detection. METHODS In 304 individuals without dementia, we investigated whether C2N Diagnostics’...
