by Clinical Neuropsychologist | Wednesday, May 1, 2024 | Dementia
Abstract This article describes the public health impact of Alzheimer’s disease (AD), including prevalence and incidence, mortality and morbidity, use and costs of care and the ramifications of AD for family caregivers, the dementia workforce and society. The...
by Clinical Neuropsychologist | Tuesday, April 30, 2024 | Dementia
Abstract INTRODUCTION Genome-wide association studies have identified over 70 genetic loci associated with late-onset Alzheimer’s disease (LOAD), but few candidate polymorphisms have been functionally assessed for disease relevance and mechanism of action....
by Clinical Neuropsychologist | Tuesday, April 30, 2024 | Dementia
Abstract Experimental laboratory research has an important role to play in dementia prevention. Mechanisms underlying modifiable risk factors for dementia are promising targets for dementia prevention but are difficult to investigate in human populations due to...
by Clinical Neuropsychologist | Tuesday, April 30, 2024 | Dementia
Abstract INTRODUCTION Previous approaches pursuing in vivo staging of tau pathology in Alzheimer’s disease (AD) have typically relied on neuropathologically defined criteria. In using predefined systems, these studies may miss spatial deposition patterns which...
by Clinical Neuropsychologist | Sunday, April 28, 2024 | Dementia
Abstract INTRODUCTION Increasing evidence suggests that metabolic impairments contribute to early Alzheimer’s disease (AD) mechanisms and subsequent dementia. Signals in metabolic pathways conserved across species can facilitate translation. METHODS We...
