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The presenilin 1 mutation P436S causes familial Alzheimer’s disease with elevated Aβ43 and atypical clinical manifestations

by Clinical Neuropsychologist Online | Sunday, June 2, 2024 | Dementia

Abstract INTRODUCTION Familial Alzheimer’s disease (fAD) is heterogeneous in terms of age at onset and clinical presentation. A greater understanding of the pathogenicity of fAD variants and how these contribute to heterogeneity will enhance our understanding of...

Time perception among people living with and without dementia: A scoping review

by Clinical Neuropsychologist Online | Saturday, June 1, 2024 | Dementia

Dementia, Volume 23, Issue 7, Page 1183-1211, October 2024. Dementia often manifests with profound alterations in perception, but it is unclear if and to what extent time perception is altered among people living with dementia compared to those experiencing normal...

“Brain‐IT”: Exergame training with biofeedback breathing in neurocognitive disorders

by Clinical Neuropsychologist Online | Thursday, May 30, 2024 | Dementia

Abstract INTRODUCTION The combination of exergame-based motor-cognitive training with resonance breathing guided by heart-rate variability biofeedback (HRV-BF) targets various relevant mechanisms of action to alleviate the pathological state in mild neurocognitive...

Post‐GWAS multiomic functional investigation of the TNIP1 locus in Alzheimer’s disease highlights a potential role for GPX3

by Clinical Neuropsychologist Online | Thursday, May 30, 2024 | Dementia

Abstract INTRODUCTION Recent genome-wide association studies (GWAS) have reported a genetic association with Alzheimer’s disease (AD) at the TNIP1/GPX3 locus, but the mechanism is unclear. METHODS We used cerebrospinal fluid (CSF) proteomics data to test...

Longitudinal trajectories of Alzheimer’s disease CSF biomarkers and blood pressure in cognitively healthy subjects

by Clinical Neuropsychologist Online | Wednesday, May 29, 2024 | Dementia

Abstract INTRODUCTION We examined whether hypertension (HTN) was associated with Alzheimer’s disease-related biomarkers in cerebrospinal fluid (CSF) and how changes in blood pressure (BP) related to changes in CSF biomarkers over time. METHODS A longitudinal...
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