by Clinical Neuropsychologist | Friday, April 5, 2024 | Dementia
Abstract INTRODUCTION Apolipoprotein E4 (APOE4) carriers’ tendency toward hypercholesterolemia may contribute to Alzheimer’s disease (AD) risk through oxysterols, which traverse the blood-brain barrier. METHODS Relationships between baseline plasma oxysterols,...
by Clinical Neuropsychologist | Friday, April 5, 2024 | Dementia
Abstract INTRODUCTION Data-driven neuropsychological methods can identify mild cognitive impairment (MCI) subtypes with stronger associations to dementia risk factors than conventional diagnostic methods. METHODS Cluster analysis used neuropsychological data from...
by Clinical Neuropsychologist | Friday, April 5, 2024 | Dementia
Abstract INTRODUCTION Cerebral small vessel disease (SVD) and amyloid beta (Aβ) pathology frequently co-exist. The impact of concurrent pathology on the pattern of hippocampal atrophy, a key substrate of memory impacted early and extensively in dementia, remains...
by Clinical Neuropsychologist | Friday, April 5, 2024 | Dementia
Abstract INTRODUCTION Fundamental questions remain about the key mechanisms that initiate Alzheimer’s disease (AD) and the factors that promote its progression. Here we report the successful generation of the first genetically engineered marmosets that carry...
by Clinical Neuropsychologist | Friday, April 5, 2024 | Dementia
Abstract INTRODUCTION To support clinical trial designs focused on early interventions, our study determined reliable early amyloid-β (Aβ) accumulation based on Centiloids (CL) in pre-dementia populations. METHODS A total of 1032 participants from the Amyloid Imaging...
