by Clinical Neuropsychologist Online | Friday, June 21, 2024 | Dementia
Abstract INTRODUCTION The understanding of the pathological events in Alzheimer’s disease (AD) has advanced dramatically, but the successful translation from rodent models into efficient human therapies is still problematic. METHODS To examine how tau pathology...
by Clinical Neuropsychologist Online | Thursday, June 20, 2024 | Dementia
Abstract INTRODUCTION Premenopausal bilateral oophorectomy (PBO) is associated with later-life cognition, but the underlying brain changes remain unclear. We assessed the impact of PBO and PBO age on white matter integrity. METHODS Female participants with regional...
by Clinical Neuropsychologist Online | Thursday, June 20, 2024 | Dementia
Abstract INTRODUCTION Amyloid beta (Aβ) impairs the cerebral blood flow (CBF) increase induced by neural activity (functional hyperemia). Tissue plasminogen activator (tPA) is required for functional hyperemia, and in mouse models of Aβ accumulation tPA deficiency...
by Clinical Neuropsychologist Online | Thursday, June 20, 2024 | Dementia
Dementia, Volume 23, Issue 8, Page 1327-1353, November 2024. The abuse of older adults is a societal, and legal issue. A person living with dementia is at high risk for abuse due to their physical and cognitive decline.ObjectivesThis review examined the evidence for...
by Clinical Neuropsychologist Online | Wednesday, June 19, 2024 | Dementia
Abstract INTRODUCTION Arterial stiffness is linked to age-related cognitive dysfunction. Estimated pulse wave velocity (ePWV) is associated with cerebrovascular disease. We sought to determine whether ePWV was associated with cognition in a multiethnic population....
