by Clinical Neuropsychologist Online | Friday, April 5, 2024 | Dementia
Abstract INTRODUCTION Cerebral small vessel disease (SVD) and amyloid beta (Aβ) pathology frequently co-exist. The impact of concurrent pathology on the pattern of hippocampal atrophy, a key substrate of memory impacted early and extensively in dementia, remains...
by Clinical Neuropsychologist Online | Friday, April 5, 2024 | Dementia
Abstract INTRODUCTION Fundamental questions remain about the key mechanisms that initiate Alzheimer’s disease (AD) and the factors that promote its progression. Here we report the successful generation of the first genetically engineered marmosets that carry...
by Clinical Neuropsychologist Online | Friday, April 5, 2024 | Dementia
Abstract INTRODUCTION To support clinical trial designs focused on early interventions, our study determined reliable early amyloid-β (Aβ) accumulation based on Centiloids (CL) in pre-dementia populations. METHODS A total of 1032 participants from the Amyloid Imaging...
by Clinical Neuropsychologist Online | Thursday, April 4, 2024 | Dementia
Abstract INTRODUCTION Emerging evidence links changes in the gut microbiome to late-onset Alzheimer’s disease (LOAD), necessitating examination of AD mouse models with consideration of the microbiome. METHODS We used shotgun metagenomics and untargeted...
by Clinical Neuropsychologist Online | Thursday, April 4, 2024 | Dementia
Abstract INTRODUCTION Screening for Alzheimer’s disease neuropathologic change (ADNC) in individuals with atypical presentations is challenging but essential for clinical management. We trained automatic speech-based classifiers to distinguish frontotemporal...
