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Effect of apolipoprotein E ε4 and its modification by sociodemographic characteristics on cognitive measures in South Asians from LASI‐DAD

by Clinical Neuropsychologist Online | Wednesday, June 19, 2024 | Dementia

Abstract BACKGROUND We investigated the effects of apolipoprotein E (APOE) ε4 and its interactions with sociodemographic characteristics on cognitive measures in South Asians from the Diagnostic Assessment of Dementia for the Longitudinal Aging Study of India...

Development of a prediction model for cognitive impairment of sarcopenia using multimodal neuroimaging in non‐demented older adults

by Clinical Neuropsychologist Online | Wednesday, June 19, 2024 | Dementia

Abstract INTRODUCTION Despite prior research on the association between sarcopenia and cognitive impairment in the elderly, a comprehensive model that integrates various brain pathologies is still lacking. METHODS We used data from 528 non-demented older adults with...

Care needs of people with dementia in Tanzania and associated impact on carers: A cross-sectional, observational study

by Clinical Neuropsychologist Online | Tuesday, June 18, 2024 | Dementia

Dementia, Volume 23, Issue 6, Page 1021-1035, August 2024. Objectives: This study aimed to understand the care needs, care arrangements and burden of care for people with dementia in Northern Tanzania. Methods: This was a cross-sectional, observational study. People...

Relationships between PET and blood plasma biomarkers in corticobasal syndrome

by Clinical Neuropsychologist Online | Tuesday, June 18, 2024 | Dementia

Abstract INTRODUCTION Corticobasal syndrome (CBS) can result from underlying Alzheimer’s disease (AD) pathologies. Little is known about the utility of blood plasma metrics to predict positron emission tomography (PET) biomarker-confirmed AD in CBS. METHODS A...

Characterization of neurofibrillary tangle immunophenotype signatures to classify tangle maturity in Alzheimer’s disease

by Clinical Neuropsychologist Online | Monday, June 17, 2024 | Dementia

Abstract INTRODUCTION Tau aggregation into neurofibrillary tangles in Alzheimer’s disease (AD) is a dynamic process involving changes in tau phosphorylation, isoform composition, and morphology. To facilitate studies of tangle maturity, we developed an image...
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