by Clinical Neuropsychologist Online | Friday, May 17, 2024 | Dementia
Abstract BACKGROUND Compromised autophagy, including impaired mitophagy and lysosomal function, plays pivotal roles in Alzheimer’s disease (AD). Urolithin A (UA) is a gut microbial metabolite of ellagic acid that stimulates mitophagy. The effects of UA’s...
by Clinical Neuropsychologist Online | Thursday, May 16, 2024 | Dementia
Abstract INTRODUCTION This study investigates the effect of apolipoprotein E (APOE) genotype on neurology plasma biomarkers in cognitively healthy Super-Seniors. METHODS Three hundred seventy plasma specimens from Super-Senior participants ≥ 85 years old, who have...
by Clinical Neuropsychologist Online | Monday, May 13, 2024 | Dementia
Abstract INTRODUCTION MODEL-AD (Model Organism Development and Evaluation for Late-Onset Alzheimer’s Disease) is creating and distributing novel mouse models with humanized, clinically relevant genetic risk factors to capture the trajectory and progression of...
by Clinical Neuropsychologist Online | Thursday, May 9, 2024 | Dementia
Abstract INTRODUCTION We explored the variations of blood biomarkers of Alzheimer’s disease (AD) by chronic diseases and systemic inflammation. METHODS We explored the association of AD blood biomarkers with chronic diseases and systemic inflammation...
by Clinical Neuropsychologist Online | Wednesday, May 8, 2024 | Dementia
Abstract INTRODUCTION The use of antidepressants in major depressive disorder (MDD) has been reported to influence long-term risk of Alzheimer’s disease (AD) and AD-related dementias (AD/ADRD), but studies are conflicting. METHODS We used inverse probability...
