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General cognitive ability in high school, attained education, occupational complexity, and dementia risk

by Clinical Neuropsychologist Online | Tuesday, February 20, 2024 | Dementia

Abstract INTRODUCTION We address the extent to which adolescent cognition predicts dementia risk in later life, mediated by educational attainment and occupational complexity. METHODS Using data from Project Talent Aging Study (PTAS), we fitted two structural equation...

Sensory and motor deficits as contributors to early cognitive impairment

by Clinical Neuropsychologist Online | Tuesday, February 20, 2024 | Dementia

Abstract INTRODUCTION Age-related sensory and motor impairment are associated with risk of dementia. No study has examined the joint associations of multiple sensory and motor measures on prevalence of early cognitive impairment (ECI). METHODS Six hundred fifty...

Views of healthcare professionals on their relationships with families of people living with dementia: A qualitative study

by Clinical Neuropsychologist Online | Tuesday, February 20, 2024 | Dementia

Dementia, Volume 23, Issue 4, Page 610-621, May 2024. ObjectiveHealthcare professionals as well as families play a vital role in ensuring the quality of care for people living with dementia. However, the relationships between healthcare professionals and families of...

Three‐dimensional histology reveals dissociable human hippocampal long‐axis gradients of Alzheimer’s pathology

by Clinical Neuropsychologist Online | Monday, February 19, 2024 | Dementia

Abstract INTRODUCTION Three-dimensional (3D) histology analyses are essential to overcome sampling variability and understand pathological differences beyond the dissection axis. We present Path2MR, the first pipeline allowing 3D reconstruction of sparse human...

Tracing synaptic loss in Alzheimer’s brain with SV2A PET‐tracer UCB‐J

by Clinical Neuropsychologist Online | Friday, February 16, 2024 | Dementia

Abstract INTRODUCTION Synaptic loss is an early prominent feature of Alzheimer’s disease (AD). The recently developed novel synaptic vesicle 2A protein (SV2A) PET-tracer UCB-J has shown great promise in tracking synaptic loss in AD. However, there have been...
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