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Dynamic frailty exposure and cognitive aging trajectories: A multicohort study

by Clinical Neuropsychologist Online | Friday, September 11, 2026 | Dementia

Abstract INTRODUCTION The cognitive implications of longitudinal frailty exposure remain unclear. We examined associations of baseline frailty status, two-wave frailty change, and mean frailty burden with annual cognitive change and cognitive aging trajectories....

TMEM106B is a selective modulator of TDP‐43 pathology in Alzheimer’s disease

by Clinical Neuropsychologist Online | Thursday, September 10, 2026 | Dementia

Abstract INTRODUCTION Co-pathologies – including Lewy body, vascular, and TDP-43 lesions – are common in Alzheimer’s disease (AD), contributing to its clinical and pathological heterogeneity. Genetic risk factors may drive mixed pathology presentation, but their...

More efficient screening for preclinical Alzheimer’s clinical trials using mixture of experts

by Clinical Neuropsychologist Online | Wednesday, September 9, 2026 | Dementia

Abstract INTRODUCTION Blood plasma biomarkers identifying Alzheimer’s disease (AD) neuropathology offer accessible and scalable alternatives to lumbar puncture and positron emission tomography (PET) scans, with potential efficiency gains in clinical trial...

Time Passing: Reflections on a Career in Dementia Care

by Clinical Neuropsychologist Online | Wednesday, September 9, 2026 | Dementia

Dementia, Ahead of Print. If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at Neuro.vip. This post is Copyright: | September 9, 2026 Neuro-Dementia Previous...

Alterations of gut microbiota in Down syndrome and their association with Alzheimer’s disease

by Clinical Neuropsychologist Online | Wednesday, September 9, 2026 | Dementia

Abstract INTRODUCTION Adults with Down syndrome (DS) have a higher risk of Alzheimer’s disease (AD). As gut microbiota (GM) alterations have been reported in AD, we investigated their association with cognitive decline and plasma AD biomarkers in DS. METHODS...
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