by Clinical Neuropsychologist Online | Wednesday, August 5, 2026 | Dementia
Abstract Vascular cognitive impairment (VCI), the second leading cause of dementia, is characterized by heterogeneous pathophysiology and a potentially reversible early phase, underscoring the need for timely identification. This review synthesizes advances across...
by Clinical Neuropsychologist Online | Wednesday, August 5, 2026 | Dementia
Abstract INTRODUCTION Cerebral amyloid angiopathy (CAA) frequently co-occurs with Alzheimer’s disease (AD), generating mixed vascular–neurodegenerative phenotypes. Plasma phosphorylated tau (p-tau)217 is a robust biomarker of AD, but its performance in CAA...
by Clinical Neuropsychologist Online | Wednesday, August 5, 2026 | Dementia
Abstract INTRODUCTION Medicare patients currently access amyloid-targeting therapies for Alzheimer’s disease through the class-based National Coverage Determination (NCD) with coverage with evidence development (CED) established in 2022. Evidence addressing the...
by Clinical Neuropsychologist Online | Wednesday, August 5, 2026 | Dementia
Abstract INTRODUCTION African Americans (AAs) face a higher risk of Alzheimer’s disease and related dementias (ADRD) than European Americans (EUs), yet the utility of polygenic risk scores (PRS) in AAs remains underexplored. METHODS A standardized dementia PRS...
by Clinical Neuropsychologist Online | Tuesday, August 4, 2026 | Dementia
Abstract INTRODUCTION Subclinical lower cardiac output (volume of blood pumped per minute) cross-sectionally relates to smaller cerebral gray matter volumes in older adults. This study relates cardiac output to longitudinal gray matter volumes among middle-aged and...
