by Clinical Neuropsychologist | Friday, January 3, 2025 | Dementia
Abstract Background The brain is shielded from the peripheral circulation by central nervous system (CNS) barriers, comprising the well-known blood-brain barrier (BBB) and the less recognized blood-cerebrospinal fluid (CSF) barrier located within the brain ventricles....
by Clinical Neuropsychologist | Friday, January 3, 2025 | Dementia
Abstract Background Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by hallmark pathologies that affect many brain regions, including the cellular microenvironment with the hippocampus, ultimately leading to profound deficits in...
by Clinical Neuropsychologist | Friday, January 3, 2025 | Dementia
Abstract Background Cerebrovascular alterations and innate immune activation are key features of Alzheimer’s disease (AD). However, the mechanisms that link blood-brain barrier disruption to neurodegeneration are poorly understood and well-defined druggable targets at...
by Clinical Neuropsychologist | Friday, January 3, 2025 | Dementia
Abstract Background MicroRNAs have been linked to dementia. However, understanding their relation to cognition in the general population is required to determine their potential use for the detection and prevention of age-associated cognitive decline and preclinical...
by Clinical Neuropsychologist | Thursday, January 2, 2025 | Dementia
Abstract INTRODUCTION Whole genome methylation sequencing (WGMS) in blood identifies differential DNA methylation in persons with late-onset dementia due to Alzheimer’s disease (AD) but has not been tested in persons with mild cognitive impairment (MCI). METHODS...
