Non‐APOE variants predominately expressed in smooth muscle cells contribute to the influence of Alzheimer’s disease genetic risk on white matter hyperintensities

by | Tuesday, December 31, 2024 | Dementia

Abstract INTRODUCTION White matter hyperintensity volumes (WMHVs) are disproportionally prevalent in individuals with Alzheimer’s disease (AD), potentially reflecting neurovascular injury. We quantify the association between AD polygenic risk score (AD-PRS) and...

Guidelines for the standardization of pre‐analytical variables for salivary biomarker studies in Alzheimer’s disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group

by | Tuesday, December 31, 2024 | Dementia

Abstract There is a pressing need for accessible biomarkers with high diagnostic accuracy for Alzheimer’s disease (AD) diagnosis to facilitate widespread screening, particularly in underserved groups. Saliva is an emerging specimen for measuring AD biomarkers,...

MRI free water mediates the association between diffusion tensor image analysis along the perivascular space and executive function in four independent middle to aged cohorts

by | Tuesday, December 31, 2024 | Dementia

Abstract INTRODUCTION Diffusion tensor image analysis along the perivascular space (DTI-ALPS) index was proposed for assessing glymphatic clearance function. This study evaluated DTI-ALPS as a biomarker for cerebral small vessel disease (cSVD) related vascular...