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Appropriate use of meaningful within‐patient change (MWPC) thresholds in Alzheimer’s disease

by Clinical Neuropsychologist | Wednesday, December 18, 2024 | Dementia

Alzheimer’s &Dementia, EarlyView. If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at Neuro.vip. This post is Copyright: Claire J. Lansdall, Jeffrey L. Cummings, Jeffrey Scott Andrews...

White matter free water mediates the associations between placental growth factor, white matter hyperintensities, and cognitive status

by Clinical Neuropsychologist | Wednesday, December 18, 2024 | Dementia

Abstract INTRODUCTION Placental growth factor (PlGF) may regulate cerebrovascular permeability. We hypothesized that white matter interstitial fluid accumulation, estimated via magnetic resonance imaging (MRI) free water (FW), would explain the associations between...

Early life exposure to structural sexism and late‐life memory trajectories among black and white women and men in the United States

by Clinical Neuropsychologist | Wednesday, December 18, 2024 | Dementia

Abstract INTRODUCTION We investigated whether early life exposure to state-level structural sexism influenced late-life memory trajectories among United Staes (U.S.) -born women and men and determined whether associations differed between racialized groups. METHODS...

Post mortem validation and mechanistic study of UCB‐J in progressive supranuclear palsy patients’ brains

by Clinical Neuropsychologist | Friday, December 13, 2024 | Dementia

Abstract INTRODUCTION Progressive supranuclear palsy (PSP) is a devastating 4R tauopathy affecting motor functions and is often misdiagnosed/underdiagnosed due to a lack of specific biomarkers. Synaptic loss is an eminent feature of tauopathies including PSP. Novel...

Neuropathology of trisomy 21 mosaicism in a case with early‐onset dementia

by Clinical Neuropsychologist | Tuesday, December 10, 2024 | Dementia

Abstract INTRODUCTION This study investigated the impact of trisomy 21 mosaicism (mT21) on Alzheimer’s disease (AD) neuropathology in a well-characterized clinical case described by Ringman et al. METHODS We describe AD neuropathology in mT21 including amyloid...
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