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Unraveling the bidirectional link between cancer and dementia and the impact of cancer therapies on dementia risk: A systematic review and meta‐analysis

by Clinical Neuropsychologist | Tuesday, January 14, 2025 | Dementia

Abstract Observational studies on the cancer–dementia relationship have yielded controversial results. This study systematically reviews the evidence to clarify this association. We searched Embase, Global Health, Ovid Medline, and APA PsycInfo. Colorectal and lung...

Cognitive aging outcomes are related to both tau pathology and maintenance of cingulate cortex structure

by Clinical Neuropsychologist | Tuesday, January 14, 2025 | Dementia

Abstract INTRODUCTION Successful cognitive aging is related to both maintaining brain structure and avoiding Alzheimer’s disease (AD) pathology, but how these factors interplay is unclear. METHODS A total of 109 cognitively normal older adults (70+ years old)...

Inhibition of IFITM3 in cerebrovascular endothelium alleviates Alzheimer’s‐related phenotypes

by Clinical Neuropsychologist | Tuesday, January 14, 2025 | Dementia

Abstract INTRODUCTION Interferon-induced transmembrane protein 3 (IFITM3) modulates γ-secretase in Alzheimer’s Disease (AD). Although IFITM3 knockout reduces amyloid β protein (Aβ) production, its cell-specific effect on AD remains unclear. METHODS Single...

Neuropsychological test performance in mild cognitive impairment with Lewy bodies: A systematic review and meta‐analysis

by Clinical Neuropsychologist | Friday, January 10, 2025 | Dementia

Abstract BACKGROUND We sought to characterize the cognitive profile among individuals with mild cognitive impairment with Lewy bodies (MCI-LB) to help guide future clinical criteria. METHODS Systematic review and meta-analysis included MCI-LB studies with cognitive...

Menopausal hormone therapy is associated with worse levels of Alzheimer’s disease biomarkers in APOE ε4‐carrying women: An observational study

by Clinical Neuropsychologist | Thursday, January 9, 2025 | Dementia

Abstract INTRODUCTION Menopausal hormone therapy (MHT), along with the apolipoprotein E (APOE) ε4 allele, has been suggested as a possible risk factor for Alzheimer’s disease (AD). However, the relationship between MHT and cerebrospinal fluid (CSF) biomarkers is...
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