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Tau pathway‐based gene analysis on PET identifies CLU and FYN in a Korean cohort

by Clinical Neuropsychologist | Tuesday, December 3, 2024 | Dementia

Abstract INTRODUCTION The influence of genetic variation on tau protein aggregation, a key factor in Alzheimer’s disease (AD), remains not fully understood. We aimed to identify novel genes associated with brain tau deposition using pathway-based candidate gene...

Arterial calcification in the heart–brain axis and cognitive performance over time

by Clinical Neuropsychologist | Tuesday, December 3, 2024 | Dementia

Abstract BACKGROUND While cross-sectional studies suggest a link between arteriosclerosis and cognition, longitudinal research is lacking. We investigated how arteriosclerosis in the heart–brain axis is related to cognitive performance trajectories over time. METHODS...

Regional cerebral blood flow reflects both neurodegeneration and microvascular integrity across the Alzheimer’s continuum

by Clinical Neuropsychologist | Tuesday, December 3, 2024 | Dementia

Abstract INTRODUCTION Alzheimer’s disease (AD) typically involves both neurodegenerative and vascular pathologies, each associated with reductions in cerebral blood flow (CBF). However, it remains unclear whether vascular and neural contributions to regional CBF...

Metaphor as methodology: Methodological reflections on visualizing the dementia journey

by Clinical Neuropsychologist | Monday, December 2, 2024 | Dementia

Dementia, Volume 24, Issue 2, Page 193-213, February 2025. Metaphors to describe and understand dementia have been used in Western culture for many years. However, the ways in which people living with dementia and care partners use metaphors and symbols to illustrate...

ADNI Biomarker Core: A review of progress since 2004 and future challenges

by Clinical Neuropsychologist | Saturday, November 30, 2024 | Dementia

Abstract BACKGROUND We describe the Alzheimer’s Disease Neuroimaging Initiative (ADNI) Biomarker Core major activities from October 2004 to March 2024, including biobanking ADNI cerebrospinal fluid (CSF), plasma, and serum biofluid samples, biofluid analyses for...
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