The risk of Alzheimer’s disease and cognitive impairment characteristics in eight mental disorders: A UK Biobank observational study and Mendelian randomization analysis

Abstract INTRODUCTION The cognitive impairment patterns and the association with Alzheimer’s disease (AD) in mental disorders remain poorly understood. METHODS We analyzed data from 486,297 UK Biobank participants, categorizing them by mental disorder history to...

Unraveling the multiple chronic conditions patterns among people with Alzheimer’s disease and related dementia: A machine learning approach to incorporate synergistic interactions

Abstract INTRODUCTION Most people with Alzheimer’s disease and related dementia (ADRD) also suffer from two or more chronic conditions, known as multiple chronic conditions (MCC). While many studies have investigated the MCC patterns, few studies have considered...