Integrating rare pathogenic variant prioritization with gene‐based association analysis to identify novel genes and relevant multimodal traits for Alzheimer’s disease

by | Monday, December 23, 2024 | Dementia

Abstract INTRODUCTION Increasing evidence has highlighted rare variants in Alzheimer’s disease (AD). However, insufficient sample sizes, especially in underrepresented ethnic groups, hinder their investigation. Additionally, their impact on endophenotypes...

Lewy body co‐pathology in Alzheimer’s disease and primary age‐related tauopathy contributes to differential neuropathological, cognitive, and brain atrophy patterns

by | Monday, December 23, 2024 | Dementia

Abstract INTRODUCTION Alzheimer’s disease (AD) co-pathology with Lewy bodies (LB) is frequent and influences clinical manifestations and outcomes. Its significance in primary age-related tauopathy (PART) is unknown. We investigated the influence of LB on...