by Clinical Neuropsychologist | Friday, December 6, 2024 | Dementia
Abstract INTRODUCTION Using a single-nucleus transcriptome derived from the dorsolateral prefrontal cortex of 424 Religious Orders Study and the Rush Memory and Aging Project (ROS/MAP) participants, we investigated the cell type–specific effect of ten vascular...
by Clinical Neuropsychologist | Tuesday, December 3, 2024 | Dementia
Abstract The revised biomarker framework for diagnosis and staging of Alzheimer’s disease (AD) relies on amyloid beta (Aβ) and tau pathologies as core markers, and markers for adjacent pathophysiology, such as neurodegeneration and inflammation. Many of the core...
by Clinical Neuropsychologist | Tuesday, December 3, 2024 | Dementia
Abstract INTRODUCTION The influence of genetic variation on tau protein aggregation, a key factor in Alzheimer’s disease (AD), remains not fully understood. We aimed to identify novel genes associated with brain tau deposition using pathway-based candidate gene...
by Clinical Neuropsychologist | Tuesday, December 3, 2024 | Dementia
Abstract BACKGROUND While cross-sectional studies suggest a link between arteriosclerosis and cognition, longitudinal research is lacking. We investigated how arteriosclerosis in the heart–brain axis is related to cognitive performance trajectories over time. METHODS...
by Clinical Neuropsychologist | Tuesday, December 3, 2024 | Dementia
Abstract INTRODUCTION Alzheimer’s disease (AD) typically involves both neurodegenerative and vascular pathologies, each associated with reductions in cerebral blood flow (CBF). However, it remains unclear whether vascular and neural contributions to regional CBF...
