by Clinical Neuropsychologist | Saturday, April 27, 2024 | Dementia
Abstract INTRODUCTION Animal research has shown that tau pathology in the locus coeruleus (LC) is associated with reduced norepinephrine signaling, lower projection density to the medial temporal lobe (MTL), atrophy, and cognitive impairment. We investigated the...
by Clinical Neuropsychologist | Saturday, April 27, 2024 | Dementia
Abstract INTRODUCTION This study delineated the interrelationships between subclinical alterations in the left heart, cerebrospinal fluid (CSF), Alzheimer’s disease (AD) biomarkers, and cognition. METHODS Multiple linear regressions were conducted in 1244...
by Clinical Neuropsychologist | Saturday, April 27, 2024 | Dementia
Abstract INTRODUCTION The LIfestyle for BRAin Health (LIBRA) index yields a dementia risk score based on modifiable lifestyle factors and is validated in Western samples. We investigated whether the association between LIBRA scores and incident dementia is moderated...
by Clinical Neuropsychologist | Friday, April 26, 2024 | Dementia
Abstract INTRODUCTION Amyloid beta and tau pathology are the hallmarks of sporadic Alzheimer’s disease (AD) and autosomal dominant AD (ADAD). However, Lewy body pathology (LBP) is found in ≈ 50% of AD and ADAD brains. METHODS Using an α-synuclein seed...
by Clinical Neuropsychologist | Friday, April 26, 2024 | Dementia
Dementia, Volume 23, Issue 5, Page 779-799, July 2024. ObjectivesSeveral 100,000s of people living with dementia in the UK are cared for at home by a spouse or relative. Few studies have considered the ICT needs and experiences of unpaid carers. This study explores...