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External validation of dementia prediction models in Black or African American and White older adults: A longitudinal population‐based study in the United States

by Clinical Neuropsychologist | Saturday, October 12, 2024 | Dementia

Abstract INTRODUCTION Identifying people at high risk of Alzheimer’s disease (AD) dementia allows for timely intervention, which, if successful, will result in preventing or delaying the onset of the disease. METHODS Utilizing data from the Chicago Health and...

A multilayer network analysis of Alzheimer’s disease pathogenesis: Roles for p‐tau, synaptic peptides, and physical activity

by Clinical Neuropsychologist | Saturday, October 12, 2024 | Dementia

Abstract INTRODUCTION In the aging brain, cognitive abilities emerge from the coordination of complex pathways arising from a balance between protective lifestyle and environmental factors and accumulation of neuropathologies. METHODS As part of the Rush Memory and...

Head‐to‐head comparison of leading blood tests for Alzheimer’s disease pathology

by Clinical Neuropsychologist | Saturday, October 12, 2024 | Dementia

Abstract INTRODUCTION Blood tests have the potential to improve the accuracy of Alzheimer’s disease (AD) clinical diagnosis, which will enable greater access to AD-specific treatments. This study compared leading commercial blood tests for amyloid pathology and...

Amyloid PET detects the deposition of brain Aβ earlier than CSF fluid biomarkers

by Clinical Neuropsychologist | Friday, October 11, 2024 | Dementia

Abstract INTRODUCTION Understanding the relationship between amyloid beta (Aβ) positron emission tomography (PET) and Aβ cerebrospinal fluid (CSF) biomarkers will define their potential utility in Aβ treatment. Few population-based or neuropathologic comparisons have...

Implementation and validation of face de‐identification (de‐facing) in ADNI4

by Clinical Neuropsychologist | Friday, October 11, 2024 | Dementia

Abstract INTRODUCTION Recent technological advances have increased the risk that de-identified brain images could be re-identified from face imagery. The Alzheimer’s Disease Neuroimaging Initiative (ADNI) is a leading source of publicly available de-identified...
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