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Regional variation in diagnostic intensity of dementia among older US adults: An observational study

by Clinical Neuropsychologist | Sunday, October 6, 2024 | Dementia

Alzheimer’s &Dementia, EarlyView. If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at Neuro.vip. This post is Copyright: Xinyue Yang, Man Yin, Zhiqiang Zhang | October 6, 2024 Wiley:...

Salience network segregation mediates the effect of tau pathology on mild behavioral impairment

by Clinical Neuropsychologist | Friday, October 4, 2024 | Dementia

Abstract INTRODUCTION A recently developed mild behavioral impairment (MBI) diagnostic framework standardizes the early characterization of neuropsychiatric symptoms in older adults. However, the joint contributions of Alzheimer’s disease (AD) pathology and...

Widespread transposable element dysregulation in human aging brains with Alzheimer’s disease

by Clinical Neuropsychologist | Wednesday, October 2, 2024 | Dementia

Abstract Introduction Transposable element (TE) dysregulation is associated with neuroinflammation in Alzheimer’s disease (AD) brains. Yet, TE quantitative trait loci (teQTL) have not been well characterized in human aged brains with AD. Methods We leveraged...

Evaluating the updated LATE‐NC staging criteria using data from NACC

by Clinical Neuropsychologist | Tuesday, October 1, 2024 | Dementia

Abstract INTRODUCTION Limbic-predominant age-related TAR DNA-binding protein of 43 kDa encephalopathy neuropathologic change (LATE-NC) staging criteria were updated in 2023. We evaluated this updated staging using National Alzheimer’s Coordinating Center data....

Cerebral small vessel injury in mice with damage to ACE2‐expressing cerebral vascular endothelial cells and post COVID‐19 patients

by Clinical Neuropsychologist | Tuesday, October 1, 2024 | Dementia

Abstract Introduction The angiotensin-converting enzyme 2 (ACE2), which is expressed in cerebral vascular endothelial cells (CVECs), has been currently identified as a functional receptor for SARS-CoV-2. Methods We specifically induced injury to ACE2-expressing CVECs...
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