by Clinical Neuropsychologist | Thursday, September 26, 2024 | Dementia
Abstract INTRODUCTION Hearing loss is identified as one of the largest modifiable risk factors for cognitive impairment and dementia. Studies evaluating this relationship have yielded mixed results. METHODS We investigated the longitudinal relationship between...
by Clinical Neuropsychologist | Thursday, September 26, 2024 | Dementia
Abstract INTRODUCTION We investigated longitudinal associations between self-reported exercise and Alzheimer’s disease (AD)-related biomarkers in individuals with autosomal dominant AD (ADAD) mutations. METHODS Participants were 308 ADAD mutation carriers aged...
by Clinical Neuropsychologist | Wednesday, September 25, 2024 | Dementia
Abstract INTRODUCTION Electro-acupuncture (EA) has demonstrated potential in improving mild-to-moderate dementia in clinics, but the underlying scientific target remains unclear. METHODS EA was administered to APP/PS1 Alzheimer’s disease (AD) mice, with...
by Clinical Neuropsychologist | Wednesday, September 25, 2024 | Dementia
Abstract INTRODUCTION Small molecules and antibodies are being developed to lower amyloid beta (Aβ) peptides. METHODS We describe MEDI1814, a fully human high-affinity monoclonal antibody selective for Aβ42, the pathogenic self-aggregating species of Aβ. RESULTS...
by Clinical Neuropsychologist | Wednesday, September 25, 2024 | Dementia
Abstract INTRODUCTION The Alzheimer’s Prevention Initiative (API) Generation Studies evaluated the BACE inhibitor umibecestat for Alzheimer’s disease (AD) prevention. The studies were terminated early, and the reversibility of umibecestat’s side...
