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Modifiable dementia risk factors associated with objective and subjective cognition

by Clinical Neuropsychologist | Wednesday, October 9, 2024 | Dementia

Abstract INTRODUCTION Early detection of both objective and subjective cognitive impairment is important. Subjective complaints in healthy individuals can precede objective deficits. However, the differential associations of objective and subjective cognition with...

LEAP! Rx: A randomized trial of a pragmatic approach to lifestyle medicine

by Clinical Neuropsychologist | Tuesday, October 8, 2024 | Dementia

Abstract INTRODUCTION Clinicians lack the tools to incorporate physical activity into clinical care for Alzheimer’s disease prevention. We tested a 52-week exercise and health education program (Lifestyle Empowerment for Alzheimer’s Prevention [LEAP! Rx])...

Genetic analysis of cognitive preservation in the midwestern Amish reveals a novel locus on chromosome 2

by Clinical Neuropsychologist | Tuesday, October 8, 2024 | Dementia

Abstract INTRODUCTION Alzheimer’s disease (AD) remains a debilitating condition with limited treatments and additional therapeutic targets needed. Identifying AD protective genetic loci may identify new targets and accelerate identification of therapeutic...

Untangling the complex web of avoidable nursing home‐to‐hospital transfers of residents with dementia

by Clinical Neuropsychologist | Sunday, October 6, 2024 | Dementia

Abstract INTRODUCTION Nursing home (NH) residents with Alzheimer’s disease or related dementias (ADRD) are at high risk for hospital transfer. We aimed to (1) describe characteristics and predictors of avoidable transfer of residents with ADRD and (2) explore...

CSF complement proteins are elevated in prodromal to moderate Alzheimer’s disease patients and are not altered by the anti‐tau antibody semorinemab

by Clinical Neuropsychologist | Sunday, October 6, 2024 | Dementia

Abstract INTRODUCTION Growing evidence suggests a role for neuroinflammation in Alzheimer’s disease (AD). We investigated complement pathway activity in AD patient cerebrospinal fluid (CSF) and evaluated its modulation by the anti-tau antibody semorinemab....
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