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Examination of plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation in former elite American football players

by Clinical Neuropsychologist | Tuesday, October 1, 2024 | Dementia

Abstract INTRODUCTION Blood-based biomarkers offer a promising approach for the detection of neuropathologies from repetitive head impacts (RHI). We evaluated plasma biomarkers of amyloid, tau, neurodegeneration, and inflammation in former football players. METHODS...

Psychological outcomes of dementia risk estimation in MCI patients: Results from the PreDADQoL project

by Clinical Neuropsychologist | Tuesday, October 1, 2024 | Dementia

Abstract INTRODUCTION Understanding the impact of biomarker-based dementia risk estimation in people with mild cognitive impairment (MCI) and their care partners is critical for patient care. METHODS MCI patients and study partners were counseled on Alzheimer’s...

Socioeconomic and medical determinants of state‐level subjective cognitive decline in the United States

by Clinical Neuropsychologist | Tuesday, October 1, 2024 | Dementia

Abstract INTRODUCTION It is important to understand the socioeconomic and medical determinants of subjective cognitive decline (SCD) at a population level in the United States. METHODS The primary outcomes are state-level rates of SCD and SCD-related functional...

Recommendations for clinical implementation of blood‐based biomarkers for Alzheimer’s disease

by Clinical Neuropsychologist | Tuesday, October 1, 2024 | Dementia

Abstract Blood-based biomarkers (BBM) for Alzheimer’s disease (AD) are being increasingly used in clinical practice to support an AD diagnosis. In contrast to traditional diagnostic modalities, such as amyloid positron emission tomography and cerebrospinal fluid...

Deletion of miR‐33, a regulator of the ABCA1–APOE pathway, ameliorates neuropathological phenotypes in APP/PS1 mice

by Clinical Neuropsychologist | Monday, September 30, 2024 | Dementia

Abstract INTRODUCTION Rare variants in ABCA1 increase the risk of developing Alzheimer’s disease (AD). ABCA1 facilitates the lipidation of apolipoprotein E (apoE). This study investigated whether microRNA-33 (miR-33)-mediated regulation of this ABCA1–APOE...
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