by Clinical Neuropsychologist | Friday, September 6, 2024 | Dementia
Abstract Biological and clinical heterogeneity is a major challenge in research for developing new treatments for Alzheimer’s disease (AD). AD may be defined by its amyloid beta and tau pathologies, but we recognize that mixed pathologies are common, and that...
by Clinical Neuropsychologist | Friday, September 6, 2024 | Dementia
Abstract INTRODUCTION Cardiovascular health is important for brain aging, yet its role in the clinical manifestation of autosomal dominant or atypical forms of dementia has not been fully elucidated. We examined relationships between Life’s Simple 7 (LS7) and...
by Clinical Neuropsychologist | Friday, September 6, 2024 | Dementia
Abstract BACKGROUND Digital cognitive assessments, particularly those that can be done at home, present as low-burden biomarkers for participants and patients alike, but their effectiveness in the diagnosis of Alzheimer’s disease (AD) or predicting its...
by Clinical Neuropsychologist | Friday, September 6, 2024 | Dementia
Abstract BACKGROUND The Mnemonic Similarity Task (MST) is a popular memory task designed to assess hippocampal integrity. We assessed whether analyzing MST performance using a multinomial processing tree (MPT) cognitive model could detect individuals with elevated...
by Clinical Neuropsychologist | Thursday, September 5, 2024 | Dementia
Abstract INTRODUCTION Neuroanatomical normative modeling captures individual variability in Alzheimer’s disease (AD). Here we used normative modeling to track individuals’ disease progression in people with mild cognitive impairment (MCI) and patients with AD....
