by Clinical Neuropsychologist | Monday, September 2, 2024 | Dementia
Abstract INTRODUCTION Brain network dynamics have been extensively explored in patients with amnestic mild cognitive impairment (aMCI); however, differences in single- and multiple-domain aMCI (SD-aMCI and MD-aMCI) remain unclear. METHODS Using multicenter datasets,...
by Clinical Neuropsychologist | Saturday, August 31, 2024 | Dementia
Abstract INTRODUCTION CD33 rs3865444 and hypertension (HTN) are related to cognitive impairment, individually. However, little is known about their combined effects on cognitive function in older adults. METHODS This population-based study included 4368 dementia-free...
by Clinical Neuropsychologist | Saturday, August 31, 2024 | Dementia
Abstract INTRODUCTION Multi-omics studies in Alzheimer’s disease (AD) revealed many potential disease pathways and therapeutic targets. Despite their promise of precision medicine, these studies lacked Black Americans (BA) and Latin Americans (LA), who are...
by Clinical Neuropsychologist | Saturday, August 31, 2024 | Dementia
Abstract INTRODUCTION Anti-amyloid antibody therapies such as lecanemab are increasingly being used to treat Alzheimer’s disease (AD). These therapies are associated with a high rate of amyloid-related imaging abnormalities (ARIA). METHODS We review the case...
by Clinical Neuropsychologist | Friday, August 30, 2024 | Dementia
Abstract INTRODUCTION Cellular prion protein (PrPC) was implicated in amyloid beta (Aβ)-induced toxicity in Alzheimer’s disease (AD), but the precise molecular mechanisms involved in this process are unclear. METHODS Double transgenic mice were generated by...
