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The role of the Alzheimer’s Association in the genesis of Alzheimer’s Disease Neuroimaging Initiative

by Clinical Neuropsychologist | Friday, September 6, 2024 | Dementia

Abstract Here we highlight the Alzheimer’s Association’s role since its inception, as a strategic collaborator with National Institutes of Health–National Institute on Aging in the development of the modern era of the Alzheimer’s Movement and in...

Pathways to personalized medicine—Embracing heterogeneity for progress in clinical therapeutics research in Alzheimer’s disease

by Clinical Neuropsychologist | Friday, September 6, 2024 | Dementia

Abstract Biological and clinical heterogeneity is a major challenge in research for developing new treatments for Alzheimer’s disease (AD). AD may be defined by its amyloid beta and tau pathologies, but we recognize that mixed pathologies are common, and that...

Better cardiovascular health is associated with slowed clinical progression in autosomal dominant frontotemporal lobar degeneration variant carriers

by Clinical Neuropsychologist | Friday, September 6, 2024 | Dementia

Abstract INTRODUCTION Cardiovascular health is important for brain aging, yet its role in the clinical manifestation of autosomal dominant or atypical forms of dementia has not been fully elucidated. We examined relationships between Life’s Simple 7 (LS7) and...

Digital cognitive assessments as low‐burden markers for predicting future cognitive decline and tau accumulation across the Alzheimer’s spectrum

by Clinical Neuropsychologist | Friday, September 6, 2024 | Dementia

Abstract BACKGROUND Digital cognitive assessments, particularly those that can be done at home, present as low-burden biomarkers for participants and patients alike, but their effectiveness in the diagnosis of Alzheimer’s disease (AD) or predicting its...

Cognitive modeling of the Mnemonic Similarity Task as a digital biomarker for Alzheimer’s disease

by Clinical Neuropsychologist | Friday, September 6, 2024 | Dementia

Abstract BACKGROUND The Mnemonic Similarity Task (MST) is a popular memory task designed to assess hippocampal integrity. We assessed whether analyzing MST performance using a multinomial processing tree (MPT) cognitive model could detect individuals with elevated...
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