by Clinical Neuropsychologist | Thursday, September 5, 2024 | Dementia
Abstract INTRODUCTION Neuroanatomical normative modeling captures individual variability in Alzheimer’s disease (AD). Here we used normative modeling to track individuals’ disease progression in people with mild cognitive impairment (MCI) and patients with AD....
by Clinical Neuropsychologist | Thursday, September 5, 2024 | Dementia
Abstract INTRODUCTION Loneliness has a rising public health impact, but research involving neuropathology and representative cohorts has been limited. METHODS Inverse odds of selection weights were generalized from the autopsy sample of Rush Alzheimer’s Disease...
by Clinical Neuropsychologist | Wednesday, September 4, 2024 | Dementia
Abstract BACKGROUND The number of people with dementia is increasing in Japan, and establishing evidence for preventing dementia is necessary. METHODS This study was a randomized controlled trial in cognitively normal community-dwelling older adults aged 65 to 85 with...
by Clinical Neuropsychologist | Wednesday, September 4, 2024 | Dementia
Abstract INTRODUCTION Dementia often involves comorbid Alzheimer’s and vascular pathology, but their combined impact warrants additional study. METHODS We analyzed the Systolic Blood Pressure Intervention Trial and categorized white matter hyperintensity (WMH)...
by Clinical Neuropsychologist | Monday, September 2, 2024 | Dementia
Abstract INTRODUCTION The relationship between cerebrovascular disease (CVD) and amyloid beta (Aβ) in Alzheimer’s disease (AD) is understudied. We hypothesized that magnetic resonance imaging (MRI)–based CVD biomarkers—including cerebral microbleeds (CMBs),...
