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Parallel electrophysiological abnormalities due to COVID‐19 infection and to Alzheimer’s disease and related dementia

by Clinical Neuropsychologist | Thursday, August 29, 2024 | Dementia

Abstract Many coronavirus disease 2019 (COVID-19) positive individuals exhibit abnormal electroencephalographic (EEG) activity reflecting “brain fog” and mild cognitive impairments even months after the acute phase of infection. Resting-state EEG abnormalities include...

Blood DNA methylomic signatures associated with CSF biomarkers of Alzheimer’s disease in the EMIF‐AD study

by Clinical Neuropsychologist | Wednesday, August 28, 2024 | Dementia

Abstract INTRODUCTION We investigated blood DNA methylation patterns associated with 15 well-established cerebrospinal fluid (CSF) biomarkers of Alzheimer’s disease (AD) pathophysiology, neuroinflammation, and neurodegeneration. METHODS We assessed DNA...

Blood‐based multivariate methylation risk score for cognitive impairment and dementia

by Clinical Neuropsychologist | Wednesday, August 28, 2024 | Dementia

Abstract INTRODUCTION The established link between DNA methylation and pathophysiology of dementia, along with its potential role as a molecular mediator of lifestyle and environmental influences, positions blood-derived DNA methylation as a promising tool for early...

How fiber bundle alterations differ in presumed LATE and amnestic Alzheimer’s disease

by Clinical Neuropsychologist | Wednesday, August 28, 2024 | Dementia

Abstract INTRODUCTION Typical Alzheimer’s disease (AD) and limbic-predominant age-related TAR DNA-binding protein 43 (TDP-43) encephalopathy (LATE) are two neurodegenerative diseases that present with a similar initial amnestic clinical phenotype but are...

The moderating role of information processing speed in the relationship between brain remodeling and episodic memory in amnestic mild cognitive impairment

by Clinical Neuropsychologist | Wednesday, August 28, 2024 | Dementia

Abstract INTRODUCTION The role of information processing speed (IPS) on relationships between episodic memory (EM) and central remodeling features in amnestic mild cognitive impairment (aMCI) was investigated. METHODS Neuropsychological evaluations and multimodal...
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