by Clinical Neuropsychologist | Monday, August 12, 2024 | Dementia
Abstract INTRODUCTION Plasma proteomic analyses of unique brain atrophy patterns may illuminate peripheral drivers of neurodegeneration and identify novel biomarkers for predicting clinically relevant outcomes. METHODS We identified proteomic signatures associated...
by Clinical Neuropsychologist | Monday, August 12, 2024 | Dementia
Abstract INTRODUCTION Dietary patterns are associated with dementia risk, but the underlying molecular mechanisms are largely unknown. METHODS We used RNA sequencing data from post mortem prefrontal cortex tissue and annual cognitive evaluations from 1204 participants...
by Clinical Neuropsychologist | Monday, August 12, 2024 | Dementia
Abstract INTRODUCTION The apolipoprotein E (APOE) ε4 allele exerts a significant influence on peripheral inflammation and neuroinflammation, yet the underlying mechanisms remain elusive. METHODS The present study enrolled 54 patients diagnosed with late-onset...
by Clinical Neuropsychologist | Monday, August 12, 2024 | Dementia
Abstract INTRODUCTION Frontotemporal dementia (FTD) can be phenotypically divided into behavioral variant FTD (bvFTD), nonfluent variant primary progressive aphasia (nfvPPA), and semantic variant PPA (svPPA). However, the neural underpinnings of this phenotypic...
by Clinical Neuropsychologist | Monday, August 12, 2024 | Dementia
Abstract INTRODUCTION The heritability of Alzheimer’s disease (AD) is estimated to be 58%–79%. However, known genes can only partially explain the heritability. METHODS Here, we conducted gene-based exome-wide association study (ExWAS) of rare variants and...
