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Increasing research study engagement in minoritized populations: An example from the Black Women Inflammation and Tau Study

by Clinical Neuropsychologist | Wednesday, August 14, 2024 | Dementia

Abstract Black women are sorely underrepresented in studies of Alzheimer’s disease and related dementias (ADRD) despite higher rates of ADRD diagnoses than in non-Hispanic White women. There are many reasons for underrepresentation, including medical mistrust,...

Omics‐derived biological modules reflect metabolic brain changes in Alzheimer’s disease

by Clinical Neuropsychologist | Wednesday, August 14, 2024 | Dementia

Abstract INTRODUCTION Brain glucose hypometabolism, indexed by the fluorodeoxyglucose positron emission tomography ([18F]FDG-PET) imaging, is a metabolic signature of Alzheimer’s disease (AD). However, the underlying biological pathways involved in these...

Metabolic dysfunctions predict the development of Alzheimer’s disease: Statistical and machine learning analysis of EMR data

by Clinical Neuropsychologist | Wednesday, August 14, 2024 | Dementia

Abstract INTRODUCTION The incidence of Alzheimer’s disease (AD) and obesity rise concomitantly. This study examined whether factors affecting metabolism, race/ethnicity, and sex are associated with AD development. METHODS The analyses included patients ≥ 65...

Standardized statistical framework for comparison of biomarkers: Techniques from ADNI

by Clinical Neuropsychologist | Wednesday, August 14, 2024 | Dementia

Abstract INTRODUCTION Well-chosen biomarkers have the potential to increase the efficiency of clinical trials and drug discovery and should show good precision as well as clinical validity. METHODS We suggest measures that operationalize these criteria and describe a...

Educational disparities in brain health and dementia across Latin America and the United States

by Clinical Neuropsychologist | Tuesday, August 13, 2024 | Dementia

Abstract BACKGROUND Education influences brain health and dementia. However, its impact across regions, specifically Latin America (LA) and the United States (US), is unknown. METHODS A total of 1412 participants comprising controls, patients with Alzheimer’s...
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