by Clinical Neuropsychologist | Monday, August 12, 2024 | Dementia
Abstract INTRODUCTION Chronic air pollution (AirPoll) is associated with accelerated cognitive decline and risk of Alzheimer’s disease (AD). Correspondingly, wild-type and AD-transgenic rodents exposed to AirPoll have increased amyloid peptides and behavioral...
by Clinical Neuropsychologist | Monday, August 12, 2024 | Dementia
Abstract INTRODUCTION We investigated the associations of leptin markers with cognitive function and magnetic resonance imaging (MRI) measures of brain atrophy and vascular injury in healthy middle-aged adults. METHODS We included 2262 cognitively healthy participants...
by Clinical Neuropsychologist | Monday, August 12, 2024 | Dementia
Abstract INTRODUCTION Information on the psychosocial impact of Alzheimer’s disease (AD) biomarker testing in adults at risk of AD is needed to inform best practices for communicating biomarker results. METHODS Ninety-nine cognitively unimpaired older adults...
by Clinical Neuropsychologist | Monday, August 12, 2024 | Dementia
Abstract INTRODUCTION Plasma proteomic analyses of unique brain atrophy patterns may illuminate peripheral drivers of neurodegeneration and identify novel biomarkers for predicting clinically relevant outcomes. METHODS We identified proteomic signatures associated...
by Clinical Neuropsychologist | Monday, August 12, 2024 | Dementia
Abstract INTRODUCTION Dietary patterns are associated with dementia risk, but the underlying molecular mechanisms are largely unknown. METHODS We used RNA sequencing data from post mortem prefrontal cortex tissue and annual cognitive evaluations from 1204 participants...
