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An unexpected molecular explanation for how tau aggregation begins in Alzheimer’s disease

by Clinical Neuropsychologist Online | Friday, May 29, 2026 | Neuroscience

Nature Neuroscience, Published online: 29 May 2026; doi:10.1038/s41593-026-02298-wDisruption of a neuronal-specific protein degradation system, the plasma membrane-bound neuroproteasome, triggers the conversion of endogenous tau into aggregates that mirror those seen...

The multiple scales of astrocytic functional units

by Clinical Neuropsychologist Online | Wednesday, May 27, 2026 | Neuroscience

Nature Neuroscience, Published online: 27 May 2026; doi:10.1038/s41593-026-02308-xAstrocytes modulate complex brain functions. These ubiquitous glial cells constitute a multilayered system of functional units that operate across multiple spatial scales, thereby...

Microglial mitochondria transfer to astrocytes via GPNMB-enriched extracellular vesicles alleviates cognitive deficits in tauopathy mice

by Clinical Neuropsychologist Online | Tuesday, May 26, 2026 | Neuroscience

Nature Neuroscience, Published online: 26 May 2026; doi:10.1038/s41593-026-02317-wIn PS19 mice, microglia-derived glycoprotein nonmetastatic melanoma protein B promotes mitochondrial extracellular vesicle secretion, enabling mitochondrial transfer to astrocytes. This...

Fixation duration on natural scenes is explained by memory encoding not processing demand

by Clinical Neuropsychologist Online | Monday, May 25, 2026 | Neuroscience

Nature Neuroscience, Published online: 25 May 2026; doi:10.1038/s41593-026-02285-1By combining magnetoencephalography and eye tracking, this study sheds light on why people fixate on some parts of natural scenes longer than others. Rather than visual complexity,...

Low-dimensional population dynamics in the brainstem gate REM sleep

by Clinical Neuropsychologist Online | Monday, May 25, 2026 | Neuroscience

Nature Neuroscience, Published online: 25 May 2026; doi:10.1038/s41593-026-02314-zLozano et al. show that REM sleep is gated by low-dimensional brainstem network dynamics, in which opposing neuron populations across the midbrain and pons determine when transitions...
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