by Clinical Neuropsychologist Online | Friday, November 15, 2024 | Neuroscience
Nature Neuroscience, Published online: 15 November 2024; doi:10.1038/s41593-024-01782-5Brain slices offer an experimental window into human neurophysiology. Using high-density microelectrode array recordings and adeno-associated virus–mediated optogenetics, the...
by Clinical Neuropsychologist Online | Thursday, November 14, 2024 | Neuroscience
Basolateral amygdala (BLA) neurons are engaged by emotionally salient stimuli. An area of increasing interest is how BLA dynamics relate to evolving reward-seeking behavior, especially under situations of uncertainty or ambiguity. Here, we recorded the activity of...
by Clinical Neuropsychologist Online | Monday, November 11, 2024 | Neuroscience
Nature Neuroscience, Published online: 11 November 2024; doi:10.1038/s41593-024-01777-2Tyrosine kinase 2 (TYK2) critically regulates tau levels and aggregation by phosphorylating tau’s tyrosine 29. Partial inhibition of TYK2 mitigates tau pathologies in cells and...
by Clinical Neuropsychologist Online | Monday, November 11, 2024 | Neuroscience
Nature Neuroscience, Published online: 11 November 2024; doi:10.1038/s41593-024-01791-4Using single-nucleus RNA sequencing from 32 donors, researchers identified distinct astrocytic gene expression programs activated across brain regions and Alzheimer’s disease...
by Clinical Neuropsychologist Online | Thursday, November 7, 2024 | Neuroscience
Psychology & Neuroscience, Vol 18(1), Mar 2025, 23-39; doi:10.1037/pne0000353Objective: Exposure to adverse childhood experiences (ACEs) can have long-lasting physiological consequences, including those on the hypothalamic–pituitary–adrenal (HPA) axis regulation....
