by Clinical Neuropsychologist | Monday, November 24, 2025 | Neuroscience
Nature Neuroscience, Published online: 24 November 2025; doi:10.1038/s41593-025-02125-8Lecanemab, a leading therapy for Alzheimer’s disease, induces an Fc-mediated transcriptional program in human microglia, linked to osteopontin and enhanced plaque phagocytosis,...
by Clinical Neuropsychologist | Monday, November 24, 2025 | Neuroscience
Nature Neuroscience, Published online: 24 November 2025; doi:10.1038/s41593-025-02111-0Examining human brain organoids and ex vivo neonatal murine cortical slices demonstrates that structured neuronal sequences emerge independently of sensory input, highlighting the...
by Clinical Neuropsychologist | Monday, November 24, 2025 | Neuroscience
Nature Neuroscience, Published online: 24 November 2025; doi:10.1038/s41593-025-02118-7In this study, the authors generated iPSC lines from more than 100 sporadic ALS cases, which recapitulated key disease phenotypes and enabled large-scale drug screening, identifying...
by Clinical Neuropsychologist | Friday, November 21, 2025 | Neuroscience
Nature Neuroscience, Published online: 21 November 2025; doi:10.1038/s41593-025-02115-wAstrocytes are associated with Alzheimer’s disease pathogenesis. We found that the transcription factor Sox9 functions to enhance astrocytic phagocytosis of Aβ plaques via MEGF10,...
by Clinical Neuropsychologist | Thursday, November 20, 2025 | Neuroscience
Nature Neuroscience, Published online: 20 November 2025; doi:10.1038/s41593-025-02079-xThe dopamine motivating animals to perform a current behavior also desensitizes local D2 dopamine receptors. Dopamine signaling is less effective in subsequent rounds, resulting in...
